Formulation and Development of Metronidazole with Natural Agent Through Biodegradable and Bio adhesive Gel

Abstract

Metronidazole is a widely used antimicrobial agent effective against anaerobic bacteria and protozoa; however, its systemic administration is often associated with side effects and reduced local bioavailability. The present study aims to develop a biodegradable and bioadhesive gel for the synergistic delivery of metronidazole in combination with a natural agent (such as curcumin, aloe vera extract, or neem extract) to enhance therapeutic efficacy. The formulation was prepared using biodegradable polymers (e.g., chitosan, carbopol, or sodium alginate) and evaluated for physicochemical properties, bioadhesion, drug release profile, and antimicrobial activity. The synergistic interaction between metronidazole and the natural agent was assessed using in vitro antimicrobial studies. Results demonstrated that the formulated gel exhibited satisfactory bioadhesive strength, controlled drug release, and enhanced antimicrobial activity compared to metronidazole alone. The combination therapy showed improved efficacy due to the complementary mechanisms of action. This study suggests that biodegradable bioadhesive gels can serve as an effective localized drug delivery system, minimizing systemic side effects while enhancing therapeutic outcomes.