FORMULATION DEVELOPMENT AND EVALUATION OF EMULGEL DRUG DELIVERY SYSTEM OF MOMETASONE FUROATE

Abstract

Emulgel formulations represent a promising avenue for delivering hydrophobic therapeutic agents by leveraging the unique characteristics of both gel and emulsion systems. This approach offers the potential to enhance drug solubility and bioavailability while providing controlled release and improved patient compliance. By incorporating hydrophobic drugs into an emulsion-based gel matrix, Emulgels aim to overcome the barriers posed by traditional gel formulations, expanding their applicability to a wider range of therapeutic compounds. In this study, the focus was on formulating Mometasone furoate, a hydrophobic drug commonly used for the treatment of topical infections, into Emulgel formulations labeled as F1 to F8. The formulations were developed using Carbopol 940 as a gelling agent and Tween 80 as a penetration enhancer. Various physicochemical parameters, including drug content, viscosity, spreadability, and in vitro diffusion, were meticulously evaluated to assess the performance and feasibility of the developed Emulgels. The viscosity studies conducted on the different formulations revealed significant variations, with formulation F4 demonstrating superior characteristics compared to the others. This suggests that the composition of the Emulgel significantly influences its rheological properties, impacting its spreadability and ultimately its efficacy in delivering the drug. Furthermore, in vitro drug release studies indicated a slower release rate from the Mometasone furoate Emulgels, confirming their potential for controlled and sustained release. The optimized Emulgel formulation, F4, exhibited enhanced drug release kinetics compared to marketed preparations, underscoring its potential for improved therapeutic outcomes. Moreover, the Emulgel approach offers several advantages over traditional dosage forms, including rapid onset of action, prolonged drug release, and cost-effectiveness. These findings highlight the potential of Emulgels as promising platforms for the local delivery of hydrophobic drugs, offering new opportunities for enhancing patient care and treatment efficacy.