Role of the Natural Super Disintegrant’s in Mouth Dissolving Tablets

Abstract

Oral route is the safest, most convenient, and economical route for administration of different drugs. Oral disintegrating tablets becoming very popular in the current scenario, as they facilely disintegrated in mouth within few seconds of the time after its administration without the need of water. Conventional dosage form has a limitations like dysphagia (arduousness in swallowing), in pediatric and geriatric patients, which have been overcome by oral disintegrating tablets. To prepare the same super disintegrating agents plays vital role. Natural Super disintegrants gained an advantage over the synthetic super disintegrants since they are chemically inert, non-toxic, less expensive, easily available, biodegradable in nature. Natural polymers like locust bean gum, banana powder, mango peel pectin and Hibiscus rosasinenses mucilage ameliorate the properties of tablet and utilized as binder, diluent, and superdisintegrants increase the solubility, dissolution of poorly water-soluble drug, decrease the disintegration time. Natural super disintegrants are obtained from various sources of natural origin and they are cost efficacious, nontoxic, biodegradable, eco-friendly, devoid of any side effect and renewable. From the different extensive literature review, It is observed that from the studies that natural polymers are safer and more efficacious than the synthetic polymers. The current review article is aimed to study the FDA-approved natural polymers utilized in fast dissolving tablets.