PROCESSING TECHNOLOGIES FOR PHARMACEUTICAL TABLETS

Abstract

Pharmaceutical oral solid dosage form have been used widely for decades mainly due to their convenience of administration and their suitability for delivery for delivery of drugs for systemic effects. The manufacture ,using high speed rotary presses where the powder material is\m comprisesedin die between rigid punches. Compression represents one ofm the important unit operations because the shape, strength and other important properties of the tablets are determined at this time. The most commonly used pharmaceutical solid dosage from today include granules, pellets, tablets and capsule can be made directly from powders or from granules pellets, or from film coated multiple units. A mixture of powder is done in order to improve flow Uniformity of contents, better compressibility, improve density and to aid pharmaceutical dosing of the actives. Orally disintegrating tablet (ODTs) has expanded much attention as a preferred alternative to conventional oral dosage form such as tablet and capsules. Conventional preparation technologies like direct compression, lyophilization, spray drying, molding, phase transitions process, melt granulation, sublimation, massm extension, etc., the use of Processing analytical technologies by the pharmaceutical industry is a response to its growing need for improved productivity in order to face the increasing competition in this field.