Evaluating the Efficacy and Comparison of Pre-Soaked Suture Material in Various Antibiotics: A Randomized Control Trial

Abstract

The present study evaluates and compares the efficacy of different antibiotic pre-soaked sutures in reducing oral microbiome. The patients who indicated for routine dental extraction and require simple interrupted suturing were the study subject. 3-0 black braided silk suture is presoaked in the three different antibiotic preparation. The total of 40 patients were divided into four groups which allocated randomly. Group A- Extraction site suturing with Metronidazole pre-soaked suture (experimental group). Group B- Extraction site suturing with black braided silk suture (control group). Group C- Extraction site suturing with Doxycycline pre-soaked suture (experimental group). Group DExtraction site suturing with cefixime pre-soaked suture (experimental suture). On seventh day, the suture was removed aseptically for microbial analysis of colony-forming units per millilitre (CFU/mL). The comparison of log₁₀ CFU/mL done among the four groups. The detailed comparison of CFU/ml between groups. Although Group B conventional multifilament silk sutures showed the highest median log CFU (8.18), followed by Groups C and D (6.23), and Group A metronidazole presoaked sutures showed a comparatively lower median (5.32), these differences were not statistically significant. The present study concluded that metronidazole pre-soaked group shows highest reduction in microbial colony and but not statistically significant.