Bacteriological Profile of Superficial Wound Infections with Focus on MRSA and Its Response to Fusidic Acid and Rifampicin

Abstract

Superficial wound infections are common clinical conditions caused by a variety of microorganisms, among which Staphylococcus aureus is one of the most prevalent pathogens. The emergence of Methicillin-Resistant Staphylococcus aureus (MRSA) has created significant challenges in the treatment of wound infections due to its resistance to multiple antibiotics. This review focuses on the bacteriological profile of superficial wound infections, with particular emphasis on MRSA and the therapeutic efficacy of fusidic acid and rifampicin. Studies indicate that MRSA is a major causative agent of skin and soft tissue infections worldwide, and combination antibiotic therapy is often required to prevent resistance development. Fusidic acid and rifampicin are widely used antistaphylococcal agents with proven effectiveness, especially when used in combination. This review summarizes current knowledge on the prevalence, microbiology, antibiotic susceptibility patterns, and therapeutic outcomes associated with these drugs in MRSA-related superficial wound infections.