Design, Synthesis and Antimicrobial Screening of Novel Benzothiazole Analogs

Abstract

Recently, in a laboratory novel series of N-(2,6-substitutedimino-6H-1,3,5-dithiazin-4-yl)benzo[d]thiazol-2-amine (IIIaa-ee) was synthesized by refluxing 2-(5-substituted-2,4-dithiobiuret)benzo[d]thiazol-2-amine (Ia-e) with alky / aryl isothiocyanates (IIa-e) in acetone medium 1:1 proportion. The structures of all the synthesized compounds were justified on the basis of chemical characteristics, elemental analysis and spectral studies and their antimicrobial screening against the gram positive and gram-negative bacteria such as S. aureus, B. Subtilis, B. Megatherium, S. typhi, E. coli, and A. Aerogenes.