Exploring the Antidiabetic Potential of Plumeria Alba in Type 2 Diabetic Animal Model

Abstract

Diabetes mellitus is a metabolic disease characterised by high blood sugar levels. Compared to allopathic medications, plant-based therapies are less harmful. Flavonoids, tannins, and alkaloids are found in the well-known medicinal plant Plumeria alba Linn (Apocynaceae). Antioxidants and terpenoids. However, it is yet unknown if Plumeria alba Linn. leaves have an antihyperglycemic effect. The hypoglycemic effects of ethanolic and aqueous leaf extractives of Plumeria alba were examined in a Streptozotocin-nicotinamide-induced Type II diabetes model and compared to the diabetic control group. The anti-diabetic effect was evaluated in albino Wistar rats. For 21 days, ethanolic and aqueous leaf extracts at 250 mg/kg b.w. and 500 mg/kg b.w. were administered to normal and experimental rats, and the measurement of the impact on blood sugar levels. The ethanolic extract at a dosage of 500 mg/kg b.w. shows a highly substantial (p<0.001) decrease in blood glucose levels compared to the diabetes control group..