Pharmacological Activities of Thiazolidinone Derivatives: A Concise Review

Abstract

A broad class of heterocyclic chemicals known as thiazolidinones has shown promise in the creation of new medicinal drugs. The wide range of biological actions of thiazolidinone derivatives is demonstrated in this review, which summarises current understanding of their potential for use in medicine. We discuss their proven effectiveness in treating a variety of illnesses, such as antibacterial, antiviral, anticancer, and anti-inflammatory uses. The emphasis is on studying their molecular mechanisms of action and clarifying the structure-activity correlations that control their pharmacological effects. Along with discussing current developments in synthetic approaches, we also draw attention to the opportunities and difficulties involved in turning these chemicals into pharmaceuticals that are therapeutically viable. For researchers looking to investigate the possible therapeutic uses of thiazolidinone derivatives, this review attempts to offer a succinct yet thorough resource.Heterocyclic systems are found in many medications and physiologically significant compounds. A unique class of heterocyclic compounds with a wide range of biological activity is thiazolidinone. Numerous researchers have been interested in investigating this skeleton's numerous potentials against various activities because to the diversity in the biological response profile. The spectrum of actions is expanded when various functional groups are successfully added to the basic thiazolidinone ring. The most significant derivative of thiazolidinone is 4-thiazolidinone. It has a substituent in positions two, three, and five and a carbonyl group at position four. In order to determine the future prospects of thiazolidinone derivatives in the medical area, this study focusses on the different biological activities of these compounds from previous studies and review efforts.