Benzothiazole Congenres and It’s Therapeutic Consequence: Mini statement

Abstract

Benzothiazole are important class of hetero compounds because it has unique and versatile scaffold for experimental design. In recent year heterocyclic compounds and their derivatives have wide range biological and pharmacological properties, Benzothiazole analogues are used in evaluating new product that possesses different biological activities. Hence their structural modification produces new derivatives causes wide range of biological and pharmacological activities such as antimicrobial, antiviral, anti-inflammatory, anti-consultant etc. This review summarises the various effect of substituent to develop new derivatives having good pharmacological properties. Benzothiazole is an organic compound bearing a heterocyclic nucleus (thiazole) which imparts a wide spectrum of biological activities to it. The significant and potent activity of benzothiazole moiety influenced distinctively by nature and position of substitutions. This review summarizes the effect of various substituents in recent trends and approaches to design and develop novel benzothiazole derivatives for anticancer potential in different cell lines by interpreting the Structure- Activity Relationship (SAR) and mechanism of action of a wide range of derivatives.