Exploring Carica Papaya Leaf-Based Preparations for Dengue Treatment: A Comprehensive Review

Abstract

The Dengue illness is a prominent worldwide health issue, especially in tropical and subtropical areas where the Aedes mosquito species reside. Despite substantial research efforts, there are currently no proven antiviral treatments available for dengue. In recent times, there has been a growing focus on the examination of alternative medicine, which encompasses the study of natural treatments produced from medicinal plants. The popularity of papaya, scientifically known as carica papaya, has risen because of its alleged therapeutic benefits, namely in the treatment of dengue fever. The purpose of this thorough review is to gather the current body of research on the possible effectiveness of formulations made from Carica papaya leaves in the treatment of dengue fever. The antiviral, immunomodulatory, and anti-inflammatory activities of Carica papaya leaf extracts are explained by thoroughly analysing in vitro research, animal models, and clinical trials to understand the pharmacological pathways involved. Additionally, we provide a summary of the different compositions and timing of administration used in scientific studies investigating the effectiveness of papaya leaf extracts in alleviating symptoms and decreasing the severity of dengue. In order to fully exploit the therapeutic benefits of Carica papaya in treating dengue fever, this study provides suggestions for future research and also evaluates the problems and constraints experienced during the present work. In order to eliminate dengue fever and improve worldwide public health results, it is crucial to create treatments that are easily accessible, reasonably priced, and secure. This study emphasises the need of combining traditional knowledge with scientific investigation.