A REVIEW ON FLOATING DRUG DELIVERY SYSTEM: AN INVENTIVE APPROACH IN GASTRO-RETENTIVE SYSTEM

Abstract

The development of an oral controlled release formulation has an incredible impact on the drug delivery area especially for the drugs with a narrow absorption window but the limitation of this approach is insufficient retention of drug in the stomach. Controlled release gastro-retentive dosage forms reside in the gastric region for long duration and thus reduce drug waste and improves bioavailability. Several other advantages are patient compliance, reduced fluctuation in plasma level, decrease intake of dose, reduced drug accumulation with limiting local and systemic side effects. Of several approaches utilized such as swelling and expanding systems, polymeric bio adhesive systems, high-density systems, modified-shape systems; the floating drug delivery system (FDDS) is the most feasible one.