Herbal Remedies for Arthritis: Advancements, Potential, and Future Prospects in Alternative Therapy

Abstract

Arthritis is a leading global cause of disability and chronic health issues, with its pathophysiology characterized by the dysregulation of pro-inflammatory cytokines and enzymes, leading to elevated levels of prostaglandins, leukotrienes, and nitric oxide. Additionally, the expression of adhesion molecule matrix metalloproteinase and the excessive proliferation of synovial fibroblasts exacerbate the condition. The transcription factor nuclear factor κβ plays a crucial role in regulating these factors. Therefore, the development of drugs targeting these pathogenic mechanisms holds promise for arthritis treatment. However, current synthetic molecules often fall short due to their toxicity, side effects, or symptom recurrence upon cessation. In light of the urgent need for alternative treatments, traditional medicine offers a rich repository of herbal therapies. Recent scientific research has demonstrated the efficacy of these remedies in managing arthritis, leading to a surge in industrial interest and clinical trials for herbal medicines in treating various ailments, including arthritis. These meticulously designed clinical trials have significantly advanced our understanding of herbal treatments for arthritis.This review delves into the potential of herbal remedies as a promising alternative for arthritis therapy, highlighting current advancements and future prospects