EFFECTIVE TARGETED DRUG DELIVERY SYSTEM AN REVIEW OF TRANSFEROSOME

Abstract

Transdermal drug delivery is considered the safest and most effective method due to its constant and prolonged half-life and prevention of first-pass metabolism, and fewer side effects. Transfersomes, a type of malleable vesicle, are widely used for effective transdermal administration of bioactive materials. Researchers have added an edge activator to the lipid bilayer structure to alter their flexibility. Transferosomes can penetrate stratum-corneum lipid lamellar areas due to osmotic force or skin moisture. They can compress or collapse to fit through a tiny aperture and lose five to ten times their initial diameter before starting again. Research is ongoing on using transferosomes for targeted cancer treatment, as they can maintain an assembly of hydrophilic and hydrophobic components.