Design, Synthesis, Characterisation and Biological Study of Pyrimidine Based Heterocycles

Abstract

A series of novel 4-(2-amino-6-(substituted phenyl)pyrimidine-4-yl)-2,6-dibromobenzene-1,3-diol, were synthesized from different substituted 2,3-dibromo-1-(3,5-dibromo-2,4-dihydroxyphenyl)-3-(substitutedphenyl)propane-1-one and guanidine hydrochloride were dissolved in ethanol. Double the quantity of sodium hydroxide was dissolved in minimum amount of water and added to reaction mixture. After 6Hrs. reflux, it was poured into 250 ml of water and recrystalized the structures of the compounds were elucidated by elemental and spectral (IR, 1H NMR,) analysis. The synthesized compounds were checked for biological evaluation i.e. antimicrobial study.