Styryl-Benzimidazoles: A Versatile Scaffold with Promising Therapeutic Potential – A Review

Abstract

Styryl-benzimidazoles represent a significant class of heterocyclic compounds known for their wide-ranging biological activities. As hybrid molecules combining the benzimidazole nucleus with a styryl group, they offer structural flexibility, allowing fine-tuning of physicochemical and pharmacological properties. Over the years, researchers have explored this scaffold for its antimicrobial, anticancer, antiviral, anti-inflammatory, and antiparasitic properties. This review provides a comprehensive, reader-friendly overview of styryl-benzimidazole derivatives, focusing on their synthesis strategies, biological activities, structure-activity relationships (SAR), and future potential in medicinal chemistry.