Itopride Hydrochloride: A Comprehensive Review on its Role in Managing Functional Dyspepsia

Abstract

Itopride HCl is a prokinetic medication used to treat gastrointestinal problems such as functional dyspepsia and gastroesophageal reflux disease (GERD). It works by blocking dopamine D2 receptors and acetylcholinesterase, which increases gastrointestinal motility and speeds up stomach emptying. This dual process causes greater acetylcholine release while decreasing dopamine-mediated regulation of gastric motility, enabling stomach emptying and alleviating symptoms including bloating, nausea, and abdominal discomfort. The medicine efficiently treats symptoms like dyspepsia, bloating, upper abdominal pain, heartburn, nausea, and vomiting. The medicine had great tolerability, with no major side effects on the QT interval, hematological markers, or hepatic and renal functions. A part from other benzamides, itopride increases colonic peristalsis and propels luminal contents, which may assist functional bowel problems.