Formulation and Evaluation of an Anti-Acne Herbal Gel Using Ginkgo Biloba, Turmeric Extract, Bergamot Oil, and Vitamin E Oil
DOI:
https://doi.org/10.62896/ijpdd.2.5.03Keywords:
Ginkgo biloba, turmeric, bergamot oil, vitaminAbstract
This study aimed to develop and evaluate a Carbopol 940-based herbal gel containing extracts of Ginkgo biloba and turmeric (Curcuma longa), combined with bergamot oil and vitamin E oil, for potential anti-acne applications. Ethanolic extracts were prepared from Ginkgo biloba leaves and turmeric rhizomes, followed by phytochemical screening. Three gel formulations were developed with varying concentrations (1%, 2%, and 3% w/w) of the combined herbal extracts, supplemented with fixed amounts of bergamot oil (0.5% w/w) and vitamin E oil (0.5% w/w). The gels were evaluated for physical appearance, antimicrobial activity, skin irritation, pH, spreadability, and viscosity. The formulations were stable, yellowish-orange, and homogeneous, with no skin irritation observed. Spreadability ranged from 32.14-37.5 g.cm/sec, viscosity varied from 17,000-264,000 cP across shear rates, and pH was between 6.8-7.5, aligning with skin physiology. Gel-III (3% w/w herbal extract) exhibited the highest antimicrobial activity against Escherichia coli (zone of inhibition: 16.5 ± 0.5 mm). The 3% w/w formulation demonstrated superior antimicrobial and physicochemical properties, suggesting its potential as an effective anti-acne topical treatment.
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