Development of a Stability-Indicating HPTLC Method for the Quantitative Analysis of Mirabegron-A Comprehensive Review

Abstract

Mirabegron, a β3-adrenoceptor agonist used for treating overactive bladder syndrome, requires robust analytical methods to ensure its stability and efficacy. High-performance thin-layer chromatography (HPTLC) has emerged as a valuable tool for the quantitative analysis of Mirabegron due to its simplicity, cost-effectiveness, and ability to separate complex mixtures. This review summarizes the development and application of stability indicating HPTLC methods for Mirabegron, focusing on methodology, validation parameters, and applications in pharmaceutical research and quality control. The method's ability to separate Mirabegron from its degradation products under various stress conditions makes it indispensable for ensuring drug potency and shelf-life. Future directions for enhancing HPTLC techniques in pharmaceutical analysis are also discussed.